电子烟对细胞有损伤？研究原型：影响和新鲜空气几乎无异
Time:2021-08-23
Views:1075
Recently, an academic paper published in "Toxicological Research and Application" once again proved the harm reduction potential of e-cigarettes. Research conclusions show that compared with cigarette smoke, e-cigarette smoke (aerosol) has a smaller effect on the gene expression of lung tissue cells, or even negligible.
Under strict experimental conditions, the cell sub-cells in a 3D human bronchial model were exposed to e-cigarette smoke, traditional cigarette smoke, and fresh air, respectively. The researchers observed cell gene expression after 4 hours and 48 hours of cell recovery, and found that cigarette smoke caused significant changes in cell gene expression. These changes were clearly reflected in oxidative stress and inflammation markers.
However, the cells exposed to the e-cigarette smoke did not change significantly, and even reacted similarly to the cells exposed to fresh air.
"We observed the cells exposed to cigarette smoke and found that there was no significant change after 4 hours, but after 48 hours, genes related to the cycle and death pathways in the cells were activated. On the contrary, those exposed to e-cigarette smoke Some indicators of the cells underneath increased slightly after 4 hours, but no gene pathway was activated after 48 hours.” The researchers said.
Experimental data shows that the damage of e-cigarette smoke to lung cells is significantly lower than that of cigarette smoke with the same nicotine dose.
This conclusion is also the same as the results of RELX’s previous research. In July, RELX and Sun Yat-sen University jointly published an academic paper in the SCI journal "Ecotoxicology and Environmental Safety", which also confirmed that the effect of e-cigarette smoke on human lung epithelial cells is much less than that of cigarette smoke under acute exposure. , To verify the harm reduction potential of e-cigarettes at the cellular level.
(Wewa and Sun Yat-sen University jointly published academic papers in the SCI journal "Ecotoxicology and Environmental Safety" to verify the harm reduction potential of e-cigarettes at the cellular level.)
In the study for wewa, the experimenters used the same nicotine concentration as the standard, and also used one of my e-cigarettes and cigarettes as experimental subjects to conduct cell viability, inflammatory response, apoptosis, cell cycle, Transcriptome sequencing series of experiments.
The data showed that there were no significant changes in the morphology, apoptosis-related indicators and inflammatory factors of the cells in the e-cigarette group. At the genetic level, a total of 8477 genes have changed in traditional cigarette cells, and only 25 genes have changed in the e-cigarette group. This study also verified that e-cigarettes have low potential toxicity and good safety.
At present, research on the safety and harm reduction potential of e-cigarettes at home and abroad is gradually improving, which has also become the basis for the public to scientifically recognize e-cigarettes. Dr. Grant O‘Connell, an American scientist and leader of academic papers in Toxicology Research and Application, believes that regulators should seriously consider these scientific research conclusions when formulating policies.
"Relevant scientific conclusions have proved that e-cigarettes can play a positive role in reducing harm." O‘Connell said, "We hope that regulators and policymakers should seriously consider the importance of these scientific evidence."
This article is reproduced on the Internet (Electronic Cigarette Research Center http://www.woyouidc.com/news/) and does not represent any views and opinions of any company
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